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So it also depends on how active you are

Consistent with our data, restoration of CAV-1 function using CSD inhibited VEGF-stimulated angiogenic signaling 31 and VEGF-induced tumor vascular permeability in mice 32
They worsen progressively without any improvement trend

There have also been studies with no significant impact by taking NAC

Maintenance therapy for patients with neurological involvement may also be more frequent, sometimes every two months rather than three, though this should be individualised based on clinical response