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Description
5-amino-1MQ reverses this process, restoring cellular capacity for fatty acid oxidation while simultaneously reducing the availability of methylation resources needed for lipogenic gene expression
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In contrast, the 2,3-diamino substitution in the 1MQ scaffold (2,3-diamino-1MQ) displayed high passive permeability (Table 1), but moderate bi-directional active transport with moderate efflux ratio (Table 2)
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