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Further evidence supporting CD38s role as a signaling molecule comes from studies targeting CD38 with soluble agonists, derived from traditional Chinese medicine, as was the case for the family of retinoids

[DOI] [PubMed] [Google Scholar] 154.Williams PA et al

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CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats
