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109 Additionally, metabolites such as 2-hydroxyglutarate, succinate, and fumarate derived from mutations in IDH1/2, FH, and SDH inhibit DNA repair pathways by repressing lysine demethylase KDM4B, resulting in abnormal excessive H3K9 methylation at DNA break sites, impairing recruitment of TIP60 and ATM, reducing end resection, and decreasing recruitment of downstream repair factors

Silicon dioxide nanoparticles induced neurobehavioral impairments by disrupting microbiota-gut-brain axis

Pediatr Res 67 , 407411 (2010)

Its accumulation can be detected after SA treatment together with AtGSTF8, AtGSTF7, and AtGSTU24 proteins (Wagner et al

Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect
