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Kupffer cells (KCs) Kupffer cells (KCs), also known as liver-resident macrophages, account for 8090% of systemic tissue macrophages and 35% of liver nonparenchymal cells, and play a central role in systemic and regional defense [44, 45]

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The use of transforming growth factor beta (TGF) molecular inhibitors can partially rescue pre-adipocyte degradation following CMA deficiency, suggesting that CMA plays a pivotal role in adipocyte differentiation by transiently inhibiting TGF signaling in pre-adipocytes (101)