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Onivyde is a low-density PEGylated irinotecan liposome from Merrimack Pharmaceuticals approved in 2015 for the treatment of patients with metastatic pancreatic cancer with a history of gemcitabine use in combination with calcium folinate and fluorouracil

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Coinjection of OVA and LPS (2 g, from Escherichia coli O111:B4, MilliporeSigma) as an adjuvant served as a positive control

These A plaque deposition and neurofibrillary tangles cause neurodegeneration and, in turn, synaptic injury and neurogenesis defects, contributing to cognitive dysfunction

Light-induced thiol oxidation of recoverin affects Rhodopsin desensitization