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Environmental factors that are collectively referred to as the exposome can contribute to ROS buildup such as chemicals like nickel (Ni 2 ), cobalt (Co 2 ), and hard-metal particles (WCCo) used to simulate hypoxia in laboratory experiments and shown to stabilize HIF-1 through ROS generation [80, 81]

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Chem Proc 10 , 67 (2022)

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West Des Moines city officials announced that their community was a finalist for Wells Fargo's new campus just as builders began to put together plans to develop what is now Jordan Creek Town Center

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