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Although our findings argue against further exploration of ALCAR/ALA (at least at the doses used here) for treatment of bipolar depression, other mitochondrial-enhancing compounds, such as N-acetylcysteine (NAC), coenzyme Q10 (CoQ10), and creatine monohydrate, might have more potent effects on mitochondrial functioning and hence greater antidepressant efficacy

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In addition to muscle degradation, Akt also promotes protein synthesis through p70S6K pathways