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These tyrosines create docking sites for a variety of adaptor proteins and direct kinase substrates including the growth factor receptor-bound protein 2 (Grb2), Grb2-associated adaptor protein (Gab1), son of sevenless (SOS), SRC homology protein tyrosine phosphatase 3 (Shp2), phosphatidylinositol-3-kinase (PI3K) and signal transducer and activator of transcription 3 (STAT3)

What this tells us is that meaningful biological activity occurs even at the lower doses

AMX0035 had shown significant slowing of disease progression and prolonged survival (40)

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It is better to take a smaller, highly absorbable dose consistently than a massive dose once a week