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The endothelial layer maintains integrity upon the majority of atherosclerotic progression, whereas it is highly permeable to LDL and the exact molecular mechanism promoting this increase in permeability is unclear

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Clostridium perfringens genome The bacterium Clostridium perfringens genome is a lone circular chromosome with additional plasmids that are extra-chromosomal, meaning that there is other DNA found outside of the nucleus [8]

It promotes inflammation via NF-B pathway activation (82) and by activating the NLRP3 inflammasome in endothelial cells and arterial walls in mice, involving mitochondrial ROS, TXNIP, and lysosomal instability (101, 134)

Functional amyloidogenesis and cytotoxicity-insights into biology and pathology