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Protocols designed for aging populations should account for delayed clearance when interpreting dose-response data or adjusting dosing frequency

In PRISMS-4, the patients who switched from a placebo to the drug showed reductions in relapse and MRI activity

Ferroptosis represents a convergence point where OS, iron accumulation, and lipid peroxidation intersect to drive cell death, providing a mechanistic link between OS and oligodendrocyte loss in MS lesions (Luoqian et al., 2022)

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Next, we tested the ability of miR-483-3p to regulate endogenous IGF-1 expression