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Activation of NF-B also induces the upregulation of matrix metalloproteinase-9 (MMP-9) (94) and elevated mitochondrial MMP-9 levels cause damage to connexin-43, a mitochondrial gap junction protein, thereby increasing mitochondrial membrane permeability

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Antioxidants stabilize free radicals by donating electrons, effectively neutralizing their reactivity without becoming unstable themselves

10.1038/s41746-024-01157-x NPJ Digit Med

Uroprotective outcomes of these phytochemicals have been found to result in diminished oxidative stress and restoration of glutathione, superoxide dismutase, and related proteins in the inflamed bladder tissue