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\n\n\n\n The compounds multimechanistic nature also makes it challenging to evaluate through conventional clinical trial frameworks, which are typically designed around single-mechanism drugs with well-defined target receptors and predictable dose-response relationships
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This epithelial damage and subsequent unrestricted paracellular permeability has been observed in graft vs host disease and gastrointestinal conditions such as Crohn's disease and ulcerative colitis [39], and may play a role after acute cardiovascular events, such as after a stroke, where damage to intestinal epithelial cells is severe [40]
By transforming into necessary cell types, stem cells can help rebuild damaged structures in the spine, such as intervertebral discs or cartilage
[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Vijayaraghavan S, Karakas C, Doostan I, Chen X, Bui T, Yi M
