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ROS can affect mitochondrial DNA which can cause modulations in the synthesis of METC components like adenosine triphosphate (ATP) production as well as the leakage of ROS into the cells cytoplasm ( Although the precise mechanism corresponding to ROS generation related to PD is still unknown, in this review, we summarize the major sources of oxidative stress generated by the DA neurons, like DA metabolism, mitochondrial dysfunction, and neuroinflammation ( Figure 1 )

Iron overload: An animal study showed that melatonin decreased the effects of iron overload on bone and stem cell death.[ref] This makes sense because melatonin is a well-known iron chelator.[ref][ref] Related article: Building Up Iron Hemochromatosis Mutations Fertility: The ovaries and follicle cells contain high levels of melatonin

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