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Hoff et al., 2024) (Fig

Numerous preclinical studies with pharmacological Nrf2 activators (e.g., sulforaphane, naringenin, curcumin) have demonstrated significant cardioprotection in MIRI models, attenuating injury, reducing infarct size, and decreasing oxidative stress, inflammation, and cell death (Wang R

However, the spectrum exhibited an additional signal at m/z = 354 with high intensity, which corresponds to glutathione sulfonic acid GSO 3 H

The 4-phosphopantetheine group also functions in the context of the folate cycle via the cytosolic ALDH1L1 (aldehyde dehydrogenase 1 family member L1) encoded enzyme and the functionally related mitochondrial ALDH1L2