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Description
Procedure Adjust the salt concentration, for example, with sodium acetate (0.3 M, pH 5.2, final concentration) or ammonium acetate (2.02.5 M, final concentration)

Findings: Preclinical models demonstrated enhanced anabolic signaling and support for tissue recovery pathways
Degenerative changes in leptomeninges are less well identified than those in the dura and are limited to collagenization and hyalinization
This strategy fundamentally reduces drug exposure in normal tissues and significantly lowers systemic toxicity

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