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3.2.2.2 Genetics related to the inflammatory response Recent studies show that genetic variations in inflammatory genes, particularly TNF- and IL-6, may accelerate DR development

Common Acne Types: Comedonal acne : Whiteheads and blackheads Inflammatory acne : Papules, pustules, and nodules Cystic acne : Deep, painful, and prone to scarring Hormonal acne : Often along the jawline, flares around menstrual cycles Conventional Treatment: Why It Often Fails Dermatology often treats acne with: Topicals : Benzoyl peroxide, salicylic acid, retinoids Antibiotics : Doxycycline, minocycline Hormonal agents : Birth control, spironolactone Isotretinoin (Accutane) : For severe cystic acne These can be helpful but often come with downsides: Temporary relief Rebound breakouts Side effects : Gut issues, liver stress, mood swings No investigation of root cause Functional medicine asks a different question: Why is your body producing acne in the first place

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The second major phase involves the conversion of GDP-D-mannose formed previously into GDP-L-galactose during three reactions catalyzed successively by GDP-D-mannose 3,5-epimerase, GDP-L-galactose phosphorylase and L-galactose 1-P phosphatase

They work from within to reduce melanin production and improve skin tone