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The rationale for these modifications is rooted in a practical challenge: tetrapeptides like Epithalon are rapidly degraded by aminopeptidases and carboxypeptidases in experimental systems, limiting the duration of exposure in research protocols

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The full-thickness excisional wound model was created on the rats dorsal skin on either side from the midline using 8 mm punch biopsies after perfect shaving and disinfection of the target region

First, the disorganized tumor vessels hinder CD8 + T cell trafficking into the TME, disable effector functions, and even kill T cells

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