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By aligning their catalytic palm subdomains, we observed that the rest of the subdomains from the RdRp domain (NTD, fingers and thumb), along with the PRNTase domain and the attached VP35 tetramer, exhibited very slight rotations relative to those in the published EBOV LVP35 structures, which results in the inward movement of each (sub)domains by approximately 2.0 to 4.8 (Fig

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