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Testosterone replacement therapy (TRT) is an option for people assigned male at birth (AMAB) who have low testosterone levels due to male hypogonadism
This undergoes a series of changes in the liver and kidneys to become its active form, known as calcitriol (or vitamin D3)
The random-effects model with Knapp-Hartung adjustment was employed to account for between-study variance and potential heterogeneity in design and outcomes
MOTS-c belongs to the overnight protocol category
