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The clinical signs and symptoms of cobalamin-related remethylation disorders may vary considerably and affect multiple organ systems, most prominently the nervous system and the bone marrow

And the metabolic endpoint being measured

B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial

If not addressed, insufficient B12 levels can impact the production of red blood cells, nerve function, and overall vitality