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In fish, phagocytic immune cells like macrophages recognise ENMs as foreign invaders and attempt to clear them, a process that can trigger the release of pro-inflammatory cytokines and further ROS production (a respiratory burst).122,123,137,141 While this is a protective response, chronic, unresolved inflammation, or frustrated phagocytosis by fibrous ENMs, can lead to tissue damage and fibrosis

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The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention