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Here the preanalyzed marketed sample solution was spiked with the standard drug solution and the % recovery was calculated

The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993

This activation contributes to the reduction of cardiomyocyte death, the decrease in infarct volume, and the improvement of cardiac function

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Esposito E, Cuzzocrea S (2010) Antiinflammatory activity of melatonin in central nervous system