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In Vivo Studies In a pioneering work on HD with rutin in 3-NP-treated rats, Suganya and Sumathi reported that oral administration of rutin (25 mg/kg and 50 mg/kg) significantly decreased protein oxidation and improved endogenous antioxidant defence system

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Steussy CN, Popov KM, Bowker-Kinley MM, Sloan RB, Harris RA, Hamilton JA

It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to adenosine diphosphate (ADP), yielding one molecule of pyruvate and one molecule of ATP

or Rutin in the level of Bach1 and KAP1, while p62 expression was decreased by 10%