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It carries a black box warning for suicidal ideation (inherited from the bupropion component), though this risk applies primarily to younger patients

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The JAK inhibitor tofacitinib rescues intestinal barrier defects caused by disrupted epithelial-macrophage interactions

In conclusion, as two anti-CD38 monoclonal antibodies, isatuximab and daratumumab, are available for use in patients with RRMM, we have provided an overview of the available evidence on mechanisms of action, differences in regulatory labeling, and clinical results from recent RRMM clinical trials for both of these antibodies

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Vukojevic J., Siroglavic M., Kasnik K., Kralj T., Stancic D., Kokot A., Kolaric D., Drmic D., Sever A.Z., Barisic I., et al