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Synthetases are ligases, in which the bond formation is usually driven by ATP hydrolysis (Figure 1B)

If a decision is made to treat serious respiratory depression in the physically-dependent patient, administration of the reversal agent should be initiated with care and by titration with smaller than usual doses of the reversal agent

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Karamian, B.A., Toci, G.R., Lambrechts, M.J., Siegel, N., Tran, K., Tecce, E., Conaway, W., Nourie, B., Canseco, J.A., Anderson, G., Radcliff, K.E., Rihn, J.A., Kurd, M.F., Kaye, D., Woods, B.I., Hilibrand, A.S., Kepler, C.K., Vaccaro, A.R., Schroeder, G.D

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