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Rates of statin usea first-line treatment for LDL-Cis quite low overall, but particularly low in adults who are Black or Hispanic.[iii] Additional factors, such as lack of health insurance or no routine location for health care, lead to the most significant disparities in care.[iv] Additional treatments may be warranted for patients unable to tolerate statins or those for whom LDL-C lowering is not optimized with statins.[v] These treatments, while effective, often have a higher price tag than statins, potentially limiting their use by individuals for whom insurance coverage is inadequate, the insurance formulary does not cover the prescribed medications, or out-of-pocket costs are high

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Low response is due in part to over-representation in patients following liver transplantation of predictors of nonresponse, predictors such as genotype 1 and high viral load