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In standard in vitro tissue culture media, free amino acids are present in artificially high concentrations with added fetal bovine serum (FBS) providing only 510% of the free extracellular protein found in in vivo serum concentrations [117]

Nature (2016) 539:2948

Published material on the related Pliva development codes PL-10, PLD-116, and PL-14736 has concentrated on preclinical wound, tissue-protection, and gastrointestinal-injury models rather than randomized human efficacy data, and the peer-reviewed record does not contain a confirmatory efficacy readout for the indications most commonly associated with BPC-157 in informal discussion

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