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12 , 13 Moderate physical activity and healthy diets promote a balanced microbiome (eg, a high Bacteroidetes to Firmicutes ratio) along with the production of neurotransmitters (eg, serotonin, dopamine), secondary bile acids, and short-chain fatty acids, including acetate, propionate, and butyrate (Figure 1)

These analgesic effects are similar to other pain management drugs, but with fewer long-term side effects

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