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A 20-Year Review of Imatinib in Chronic Phase Chronic Myeloid Leukemia Patients after Failure with Interferon Therapy

The authors noted that poor or intermediate metabolizers demonstrate reduced drug clearance, which can elevate systemic exposure and increase ADR risk, whereas rapid or ultrarapid metabolizers may experience subtherapeutic exposure and treatment failure

The findings indicate that CM enhanced the cellular viability and ECM production of DCs while CTGF and the control exhibited nonsignificant differences