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[DOI] [PubMed] [Google Scholar] Festa R

Semaglutide, a weight loss drug Food and Drug Administration (FDA) approved in 2019, can be used to control appetite and reduce cravings for unhealthy food

Vitamin B12 is the energy component

This dose must sometimes be doubled and recourse to the intramuscular route should be preferred only when patients are not very observant

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Injection-site reactions Generally well-tolerated in published Phase 1/2 data No IGF-1 elevation (key distinction from rhGH or GH-axis peptides) Known interactions No major drug-drug interactions documented in published data Contraindications Pregnancy/lactation (unstudied) Hypersensitivity REGULATORY STATUS FDA Not FDA-approved