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NO DAC human pharmacokinetics remain poorly characterized Ipamorelin human data limited to early-phase pharmacokinetic and pharmacodynamic studies with small sample sizes Safe and effective dosing parameters for humans are unknown for the blend Long-term safety of sustained GH and IGF-1 elevation through secretagogue use is unstudied in human subjects Mechanistic Understanding The 3- to 5-fold synergistic GH release figure derives primarily from animal models and in vitro work

10.1017/S1462399410001602 102 FarooquiA

While RTIs were common among MRAD32 syndrome patients, they were not reported in the two patients with KAT6B mutations in our study

Peer-reviewed and received in revised form 11 January 2022

[DOI] [PubMed] [Google Scholar] Leyvraz C., Charles R.P., Rubera I., Guitard M., Rotman S., Breiden B., et al
