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Taking a separate sublingual methylcobalamin supplement of 1000 mcg or more daily will provide significantly more B12 than the 100 mcg in the compounded ODT

This is highly speculative because: Oral bioavailability differs between species Route of administration affects systemic exposure Species differences in peptide metabolism and clearance are unknown Current Practice Patterns Current practice patterns from unregulated sources typically involve: Subcutaneous injection: 0.25-0.5 mg once or twice daily, administered near injection sites for localized effects or abdominally for systemic distribution

V.SergeyevI.RosayM.et al (2016)

Molecules 28 (20), 7132

Third-Party Testing And Stability Independent testing for potency and purity