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Moreover, nanoparticles formed by conjugating anti-CD8a F(ab)2 fragments to the surface of maleimide-functionalized PEG-PLGA polymers can target CD8 + T cells in the blood, lymphoid tissues, and tumors of mice, increase the proportion of tumor-infiltrating CD8 + T cells and make tumors more sensitive to anti-PD-1 therapy (174)

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doi: 10.3389/fmicb.2024.1319897 Received 11 October 2023 Accepted 18 November 2024 Published 02 December 2024 Volume 15 - 2024 Edited by Almagul Kushugulova, Nazarbayev University, Kazakhstan Reviewed by Li Zhang, Brown University, United States Zhanagul Khassenbekova, Kazakhstan Society of Human Microbiome Researchers, Kazakhstan Updates Copyright 2024 Tarantino, Cataldi and Citro