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Taking advantage of a robust, though simplified, in vitro model of the human BBB which has been validated for CNS drugs 32, 44, 45 , we confirmed that plasma-bioavailable (poly)phenol metabolites could be transported across the BBB endothelium

Notably, the particle size of SOR within SOR-P188-CSD exhibited a significant reduction compared to the pure drug

2014 Oct 17;7:267-74

Although there is clear evidence that MGO affects components of the BBB, the impact of MGO on the BBB as a multicellular system warrants further investigation

However, (+)-CLA-induced protective effects were diminished when Nrf2 was knocked down (Fig