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CNS neurons are one of the primary consumers of glucose, oxygen, and ATP, high levels of which are necessary for maintaining membrane potentials, synthesizing neurotransmitters, and ensuring reorganization of synaptic connections and synaptic plasticity in postnatal development
Given the drop in its activity at elevated temperatures or under denaturation conditions, the group employed a crosslinking strategy that uses biselectrophiles that target pairs of Cys to enhance its stability
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[DOI] [PubMed] [Google Scholar] 43
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