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10.1016/b978-0-12-813442-9.00007-9 25 HeubergerJ
These include: Metformin use : Metformin impairs vitamin B12 absorption in the intestine

Nonetheless, the reported findings of mitochondrial dysfunction were mostly accompanied by a reduction of mitochondrial membrane potential and therefore an increased fraction of cells with depolarized mitochondria (18, 40)

B12 is essential for a properly functioning central nervous system we know that dysfunction can lead to depression
This includes better regulation of blood sugar levels and a reduced risk of metabolic disorders such as type 2 diabetes
