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Previous investigation demonstrated EGCG reduced GDH expression to disrupt glutaminolysis in primary effusion lymphoma cells, and EGCG-induced tumor cell death was attenuated if the deficient -KG was supplemented (191)

SIRT1 can bind and retain GAPDH in the cytosol, but SIRT5 actives GAPDH via demalonylation, thereby elevating glycolytic flux

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Because CaSR maintains calcium homeostasis, its exaggerated response to calcium tells the body to excrete more calcium