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This places it in the same group as smoking, which has led to a number of headlines claiming that it means the risk from the two is the same

Research dosing (reported in studies)

Subjects who inherit two identical defective alleles may have little or no enzyme activity (e.g., for CBS)

Giving Vitamin B12 supplements is a good way to fix low platelet counts

Neuron 98 , 10801098 (2018)