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Therefore, regardless the clinical heterogeneity or underpinning genetics, the different forms of PD share a common etiology in mitochondrial dysfunction and oxidative stress

In this context, the observed downregulation of EAAT2 may not only reflect transcriptional suppression but also post-translational mechanisms related to energy deficits and transporter mislocalization

References 1 KomatsuNTakayanagiH

Yes, age significantly affects GHK-Cu clearance because glomerular filtration rate declines approximately 1% per year after age 40

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