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ROCK regulates actin cytoskeleton reorganization by phosphorylating LIM kinase and cofilin, leading to increased endothelial cell gaps, elevated vascular permeability, and infiltration of inflammatory factors, thereby exacerbating endothelial damage [36]
Lewis, A
Siepka et al., 2007)
In extreme cases, excess GABA can reduce brain activity to the extent of central nervous system depression, which causes breathing rate and heart rate to decrease, potentially leading to loss of consciousness
This produces a steric hindrance that prevents AA from being metabolized
