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doi: 10.1080/10962247.2015.1070773 Al-Adra DP, Gill RS, Axford S J, Shi X, Kneteman N, Liau SS

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Nicotine's weight effects appear to result especially from the drug's stimulation of 34 nicotine acetylcholine receptors (nAChRs), which are located on pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), leading to activation of the melanocortin circuit, which is associated with body weight

Immunosuppressed patients (renal transplantation) with DN have a higher incidence of melanoma