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A particularly compelling hypothesis is that bipolar depression is a state of decreased mitochondrial energy generation, which may be overcompensated by increased mitochondrial energy generation in mania [20,21,22,23,24,25]

We hypothesize that metabolic reprogramming is not merely a passive consequence of activation but an active driver of macrophage function
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Current Opinion in Plant Biology 13:578586 Liu, H

In fact, the amount of glutathione and the patients response to treatment seem to be linked
