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In the lysosome, the complex interacts with LAMP-2As cytoplasmic tail and is destroyed ( Autophagy plays a complex role in cancer, acting as both an inhibitor and promoter of tumor growth (Chavez-Dominguez et al., 2020

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These observations were further supported by (Metabolic Reaction Enrichment Analysis) MaREA analysis, showing selective upregulation of key enzymatic programs, confirming NOTCH1- dependent metabolic reprogramming (Supplementary Fig

Ferroptosis targeting ameliorates experimental RRMS To target ferroptosis, we have previously shown the superior in vivo efficacy of our third-generation synthetic lipophilic radical trap compound UAMC-3203 in an experimental model for multi-organ failure [31]

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