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Specifically, peptides and proteins that have been denatured or degraded can lead to adverse patient reactions such as undesired immune responses
Due to insufficient blood supply, rapidly growing tumors in vivo are often hypoxic, and it is conceivable that this could enhance the therapeutic efficacy of APR-246, both in wild type and mutant TP53-carrying tumors
Que, J.-Y
& Muders, M
Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C et al
