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Furthermore, the model is characterized by age-dependent severe synaptic impairments and neuron loss albeit without plaque formation 19,20,21,22

In parallel, our aging population is growing at a remarkable rate with the population aged 60 years or over predicted to double to 2.1 billion by 2050 [6]

[1] [2] These results should be interpreted in context: they reflect specific dose groups within obesity cohorts and may not apply across all doses, populations, or indications such as type 2 diabetes

Pathway choice between proteasomal and autophagic degradation

[6] Nanoparticle and Lipid-Based Carriers for Oral Use Nanoparticle formulations, lipid vesicles, and polymer-based capsules have received attention for their ability to protect sensitive molecules from degradation