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Following acute MI, the activated cardiac fibroblast phenotype undergoes dynamic changes from an inflammatory to a noninflammatory state, driving extracellular matrix regulation and ultimately supporting scar formation ( However, some studies indicate that the beneficial effects of CF senescence require a balance with the potentially deleterious effects of ageing

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Really appreciate your notes on the study, thank you

In the context of Epithalon, the induction of MMP2 expression might imply enhanced tissue regeneration and repair processes

Furthermore, in-vitro studies are being carried out in various laboratories, mostly using streptozotocin-induced diabetic rat/mouse models and four antidiabetic drugs explored include metformin (biguanides), sitagliptin (DPP-IV inhibitors), liraglutide (incretin mimetics) and gliclazide (sulfonyl urea receptors)