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doi: 10.1007/s10875-011-9542-6 158 Carrillo-de SauvageMAMaatoukLArnouxIPascoMSanz DiezADelahayeMet al

The chemical reaction involves the deprotonation of C4 in the A ring of the steroid substrate, thereby enabling the double bond between C5 and C6 to isomerize to a double bond between C4 and C5 (Figure 2)

Moreover, in a prospective study done in the Netherlands that followed 5,920 individuals, homozygous mutant variants of the C677T polymorphism were found to be correlated with an increased risk of PD in smokers (de Lau et al., 2005)

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In CMT4B3 fibroblasts, Myo-Ins did not improve any respiratory parameter, consistent with the requirement for intact mitochondrial function and PIP signalling to support Myo-Insmediated enhancement of mitochondrial plasticity