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Thus, serum IGF-1 levels correlates with the circulating leptin concentration in patients undergoing peritoneal dialysis and hemodialysis, but not in patients treated with conservative therapy.86 Interestingly, administration of recombinant IGF-1 decreases serum leptin concentration in patients undergoing hemodialysis

10.1016/j.psyneuen.2019.02.006 Psychoneuroendocrinology

In addition to supporting muscle growth, IGF-1 LR3 plays a crucial role in human growth and development by regulating growth hormone levels and contributing to overall body growth

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[DOI] [PMC free article] [PubMed] [Google Scholar] Myers J