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Among the most studied are starch, lignin, and polylactic acid (PLA), which have been applied in tissue scaffolds, drug delivery systems, and biomedical devices [141]

Recent studies have combined formulation optimisation with 3D-printed nasal cavity models, nasal casts, and related in vitro or ex vivo tools to quantify how formulation properties affect regional deposition and brain delivery (Maaz et al., 2021

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2.2.1 Association between increased Hcy levels and MetS While the precise mechanism underlying how HHcy contributes to MetS remains incompletely understood, substantial evidence supports HHcy as a major risk factor for MetS development